The Long Journey of TCL1 Transgenic Mice: Lessons Learned in the Last 15 Years
| Autor: | Yuri Pekarsky, Carlo M. Croce, Nicola Zanesi, Alessandra Drusco, Prasanthi Kumchala |
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| Rok vydání: | 2015 |
| Předmět: |
Genetically modified mouse
B-Lymphocytes Lymphocytic Leukemias Drug discovery Extramural T-Lymphocytes Transgene Mice Transgenic Biology Article Leukemia Lymphoid Mice transgenic Disease Models Animal Mice Drug development Proto-Oncogene Proteins Drug Discovery Immunology Genetics Animals Humans Molecular Biology Neuroscience |
| Zdroj: | Gene Expression. 16:129-135 |
| ISSN: | 1052-2166 |
| DOI: | 10.3727/105221615x14181438356256 |
| Popis: | The first transgenic mouse of the TCL1 oncogene was described more than 15 years ago, and since then, the overexpression of the gene in T- and B-cells in vivo has been extensively studied to reveal the molecular details in the pathogenesis of some lymphocytic leukemias. This review discusses the main features of the original TCL1 models and the different lines of research successively developed with particular attention to genetically compound mice and the therapeutic applications in drug development. |
| Databáze: | OpenAIRE |
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