PREIMPLANTATION GENETIC TESTING: Clinical experience of preimplantation genetic testing
| Autor: | Anick De Vos, Pieter Verdyck, Willem Verpoest, Stefanie Van De Voorde, Veerle Berckmoes, Martine De Rycke, Kathelijn Keymolen |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Embryology medicine.medical_specialty 03 medical and health sciences Patient referral 0302 clinical medicine Endocrinology Pregnancy medicine Humans Medical physics Genetic Testing Preimplantation Diagnosis Genetic testing Chromosome Aberrations 030219 obstetrics & reproductive medicine medicine.diagnostic_test business.industry Genetic Diseases Inborn Obstetrics and Gynecology Cell Biology Embryo biopsy Fetal Diseases 030104 developmental biology Reproductive Medicine Female business Healthcare system |
| Zdroj: | Reproduction. 160:A45-A58 |
| ISSN: | 1741-7899 1470-1626 |
| DOI: | 10.1530/rep-20-0082 |
| Popis: | Thirty years of rapid technological advances in the field of genetic testing and assisted reproduction have reshaped the procedure of preimplantation genetic testing (PGT). The development of whole genome amplification and genome-wide testing tools together with the implementation of optimal hormonal stimulation protocols and more efficient cryopreservation methods have led to more accurate diagnoses and improved clinical outcomes. In addition, the shift towards embryo biopsy at day 5/6 has changed the timeline of a typical PGT clinical procedure. The Brussels' PGT centre started more than 25 years ago, offering PGT within a healthcare system funded by the government. In this paper, we have summarized our experience with PGT, presenting an up-to-date overview of the different steps in PGT from patient referral to baby follow-up. |
| Databáze: | OpenAIRE |
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