Towards a non-invasive interictal application of hypothermia for treating seizures: a feasibility and pilot study
| Autor: | William H. Theodore, Susumu Sato, W. Elkins, Robert Bonwetsch, Anto Bagic, E. A. Boudreau, Jeffrey P. Greenfield |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Pilot Projects Neurological disorder Article Body Temperature Central nervous system disease Epilepsy Hypothermia Induced Seizures Convulsion medicine Humans Ictal business.industry Electroencephalography General Medicine Hypothermia Middle Aged medicine.disease medicine.anatomical_structure Neurology Anesthesia Scalp Shivering Female Neurology (clinical) medicine.symptom business |
| Zdroj: | Acta neurologica Scandinavica. 118(4) |
| ISSN: | 1600-0404 |
| Popis: | Objectives – To evaluate the feasibility and safety of head-neck cooling in conscious normal volunteers (10) and patients with medically refractory epilepsy (5) without causing shivering. Patients and methods – We used a non-invasive head-neck cooling system (CoolSystems Inc., Lincoln, CA, USA). The tympanic temperature (TT) and intestinal temperature (IT) were measured as two measurements of ‘core temperature’ (CT), and multi-site external temperatures, several physiologic variables and EEG were monitored. Seizure counts over 4-week precooling, treatment and follow-up phases were compared. Results – All 15 participants completed all the cooling sessions without significant complaints. At the end of 60 min of cooling, scalp temperature fell on average by 12.2°C (P |
| Databáze: | OpenAIRE |
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