Mesothelioma mortality within two radiation monitored occupational cohorts
| Autor: | William J. Blot, Michael T. Mumma, John D. Boice, Jennifer L. Sirko |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Oncology
Mesothelioma medicine.medical_specialty Lung Neoplasms medicine.disease_cause Asbestos 030218 nuclear medicine & medical imaging Ionizing radiation 03 medical and health sciences 0302 clinical medicine Peritoneum Internal medicine Occupational Exposure Epidemiology Medicine Humans Radiology Nuclear Medicine and imaging neoplasms Radiological and Ultrasound Technology business.industry respiratory system Radiation Exposure Thorax medicine.disease respiratory tract diseases Occupational Diseases medicine.anatomical_structure 030220 oncology & carcinogenesis Nuclear Power Plants Cohort Asbestosis business |
| Zdroj: | International journal of radiation biology. 98(4) |
| ISSN: | 1362-3095 |
| Popis: | The risk of mesothelioma, including cancers of the pleura and peritoneum, was examined within two large cohorts of workers monitored for exposure to ionizing radiation.Mortality was assessed among 253,632 workers routinely monitored for external radiation, including 30,724 industrial radiographers (IR) at shipyards, 142,583 workers at nuclear power plants (NPP), and 83,441 IR who had not worked at an NPP or shipyard. Follow-up was from 1969 through 2011. Standardized mortality ratios (SMRs) and 95% confidence intervals (CIs) were computed; observed numbers of deaths from mesothelioma (including cancers of the pleura and peritoneum) and asbestosis were compared with numbers expected based on age-, sex-, and calendar year-specific national mortality rates. Job history and quantitative asbestos exposure data were unavailable, but work at a shipyard was taken as a surrogate for the likelihood of exposure. Cox proportional hazards models were used to estimate hazard ratios (HRs) for mesothelioma in relation to estimated cumulative radiation exposure to the lung.The mean duration of follow-up was 25.3 years (max 42 years). The mean cumulative lung dose was 28.6 mGy (7.3%250 mGy). Nearly 20% of the workers had died by 2011. A total of 421 mesothelioma deaths were found (75% occurring after 1999) with increased SMRs among workers monitored in shipyards (SMR 9.97; 95% CI 8.50-11.63) and for NPP workers (SMR 5.55; 95% CI 4.88-6.29), but not for IR who had not worked in shipyards (SMR 1.15; 95% CI 0.53-2.19). Likewise, deaths from asbestosis (An elevated rate of death from mesothelioma was observed in two radiation-exposed occupational groups with potential for asbestos exposure. The increased risk of death from asbestosis, combined with little evidence of a rising trend in mesothelioma mortality with increasing radiation exposure, suggests that the mesothelioma (and asbestosis) excess in these workers was due to asbestos exposure in shipyards and power plants and not to occupational low-dose radiation. |
| Databáze: | OpenAIRE |
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