Prenatal Nonylphenol and Bisphenol A Exposures and Inflammation Are Determinants of Oxidative/Nitrative Stress: A Taiwanese Cohort Study
| Autor: | Pei Wei Wang, Winnie Yang, Kuen-Yuh Wu, Chensheng Alex Lu, Li Wei Huang, Chun Hao Lai, Mei-Lien Chen, Yu Fang Huang, Hsin Chang Chen |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
0301 basic medicine endocrine system medicine.medical_specialty Antioxidant DNA damage medicine.medical_treatment Estrogen receptor Inflammation 010501 environmental sciences medicine.disease_cause 01 natural sciences Cohort Studies Toxicology Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound Phenols Pregnancy Internal medicine medicine Humans Environmental Chemistry Benzhydryl Compounds 0105 earth and related environmental sciences chemistry.chemical_classification Tumor Necrosis Factor-alpha Chemistry Glutathione peroxidase General Chemistry Fetal Blood Nonylphenol Oxidative Stress 030104 developmental biology Endocrinology Maternal Exposure Female medicine.symptom Biomarkers Oxidative stress DNA Damage |
| Zdroj: | Environmental Science & Technology. 51:6422-6429 |
| ISSN: | 1520-5851 0013-936X |
| DOI: | 10.1021/acs.est.7b00801 |
| Popis: | Prenatal exposure to nonylphenol (NP) and/or bisphenol A (BPA) has been reported to be associated with adverse birth outcomes; however, the underlying mechanisms remain unclear. The primary mechanism is endocrine disruption of the binding affinity for the estrogen receptor, but oxidative stress and inflammation might also play a contributory role. We aimed to investigate urinary NP and BPA levels in relation to biomarkers of oxidative/nitrative stress and inflammation and to explore whether changes in oxidative/nitrative stress are a function of prenatal exposure to NP/BPA and inflammation in 241 mother-fetus pairs. Third-trimester urinary biomarkers of oxidative/nitrative stress were simultaneously measured, including products of oxidatively and nitratively damaged DNA (8-hydroxy-2′-deoxyguanosine (8-OHdG) and 8-nitroguanine (8-NO2Gua)) as well as products of lipid peroxidation (8-iso-prostaglandin F2α (8-isoPF2α) and 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA)). The antioxidant glutathione peroxidase ... |
| Databáze: | OpenAIRE |
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