Signal Pathways and Markers Involved in Acute Lung Injury Induced by Acute Pancreatitis
| Autor: | Jialin Zhou, Yingyi Zhang, Zhe Fan, Pengcheng Zhou, Guangzhi Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Medicine (General)
Clinical Biochemistry Acute Lung Injury Review Article Lung injury medicine.disease_cause Bioinformatics Hypoxemia R5-920 Genetics medicine Humans Molecular Biology Lung Respiratory distress business.industry Biochemistry (medical) General Medicine respiratory system medicine.disease respiratory tract diseases medicine.anatomical_structure Pancreatitis Acute pancreatitis Signal transduction medicine.symptom Multiple organ dysfunction syndrome business Oxidative stress Biomarkers Signal Transduction |
| Zdroj: | Disease Markers Disease Markers, Vol 2021 (2021) |
| ISSN: | 1875-8630 0278-0240 |
| Popis: | Acute pancreatitis (AP) is a common acute abdominal disease with a mortality rate of about 30%. Acute lung injury (ALI) is a common systemic complication of acute pancreatitis, with progressive hypoxemia and respiratory distress as the main manifestations, which can develop into acute respiratory distress syndrome or even multiple organ dysfunction syndrome (MODS) in severe cases, endangering human health. In the model of AP, pathophysiological process of the lung can be summarized as oxidative stress injury, inflammatory factor infiltration, and alveolar cell apoptosis. However, the intrinsic mechanisms underlying AP and how it leads to ALI are not fully understood. In this paper, we summarize recent articles related to AP leading to ALI, including the signal transduction pathways and biomarkers of AP-ALI. There are factors or pathway aggravating ALI, the JAK2-STAT3 signaling pathway, NLRP3/NF-κB pathway, mitogen-activated protein kinase, PKC pathway, neutrophil protease (NP)-LAMC2-neutrophil pathway, and the P2X7 pathway, and there are important transcription factors in the NRF2 signal transduction pathway which could give researchers better understanding of the underlying mechanisms controlling AP and ALI and lay the foundation for finally curing ALI induced by AP. |
| Databáze: | OpenAIRE |
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