Elevated plasma ICAM1 levels predict 28-day mortality in cirrhotic patients with COVID-19 or bacterial sepsis
| Autor: | Arvind Tomar, Ashad Narayanan, Savneet Kaur, Chaggan Bihari, Ekta Gupta, Sadam Hussain, Guresh Kumar, Dinesh M. Tripathi, Rakhi Maiwall, Meenu Bajpai, Kailash Kolhe, Pratibha Kale, Shiv Kumar Sarin |
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| Rok vydání: | 2021 |
| Předmět: |
Liver Cirrhosis
medicine.medical_specialty Endothelial Injury Cirrhosis Ang1 Angiopoietin 1 RC799-869 Gastroenterology Article MELD Model for End-Stage Liver Disease Procalcitonin SOFA The Sequential Organ Failure Assessment law.invention Sepsis Model for End-Stage Liver Disease Von Willebrand factor law Internal medicine Internal Medicine medicine Immunology and Allergy Vegfr1 Vascular endothelial growth factor receptor 1 Neutrophil to lymphocyte ratio Covid-19 Coronavirus induced disease-19 SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 LDH Lactate Dehydrogenase Hepatology biology business.industry ALT Alanine aminotransferase Area under the curve COVID-19 NLR Neutrophil to Lymphocyte Ratio ICAM1 Intercellular adhesion molecule 1 Diseases of the digestive system. Gastroenterology medicine.disease Intensive care unit vWF von Willebrand Factor antigen CCI Charles Comorbidity Index PCT Procalcitonin ICU Intensive care unit HR Hazard Ratio Ang2 Angiopoietin 2 biology.protein AST Aspartate aminotransferase business Biomarkers |
| Zdroj: | JHEP Reports, Vol 3, Iss 4, Pp 100303-(2021) JHEP Reports |
| ISSN: | 2589-5559 |
| Popis: | Background and Aims Endothelial injury and dysfunction play a detrimental role in the pathogenesis of infections. Endothelium-related molecules have been reported as potential biomarkers for early diagnosis and/or prognosis of infections. The prognostic value of these biomarkers in patients with liver cirrhosis and infections however remain elusive. Methods In this study, we investigated the performance of key soluble endothelial injury biomarkers, including intercellular adhesion molecule 1 (ICAM1), von Willebrand Factor (vWF) antigen, vascular endothelial growth factor receptor 1 (vegfr1), angiopoietin 1 and 2 (Ang1, 2) as mortality predictors in liver cirrhosis patients with severe covid-19 or bacterial sepsis. Results A total of 66 hospitalized patients [admitted in covid-19 ward or liver intensive care unit (ICU)] were included. 22 patients had covid-19 alone while 20 patients had cirrhosis plus covid-19. 24 patients had liver cirrhosis plus bacterial sepsis. Among cirrhosis patients, most common aetiology was alcohol. ICAM1 was increased (p=0.003) while vegfr1 (p Graphical abstract |
| Databáze: | OpenAIRE |
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