Effects of desferrioxamine on 67Ga distributions in tumor-bearing mice
| Autor: | Robert G. Sephton, Sunil De Abrew |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Male
Pathology medicine.medical_specialty Iron Radioisotopes Binding Sites Time Factors Lymphoma Chemistry Vascular compartment Transferrin Soft tissue Gallium Radioisotopes Neoplasms Experimental Deferoxamine medicine.disease General Biochemistry Genetics and Molecular Biology Mice medicine Neoplasm Animals Tissue Distribution Clearance |
| Zdroj: | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 161(3) |
| ISSN: | 0037-9727 |
| Popis: | SummaryThe iron-chelating agent desferrioxamine caused approximately 10-fold reductions in 67Ga vascular concentrations and substantial (~ × 2) reductions in 67Ga concentrations of other tissues when injected iv into mice at 2 hr after 67Ga injection. Given 48 hr post 67Ga however, its only noteworthy effect was on the vascular compartment. Tumor was distinguished from other soft tissues by high concentrations of cell-bound 67Ga, of which an appreciable fraction could be chelated and cleared by desferrioxamine given 2 hr after 67Ga. This fraction diminished with time and, at 48 hr, desferrioxamine caused no significant clearance of tumor-bound 67Ga. |
| Databáze: | OpenAIRE |
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