FR901483, a Novel Immunosuppressant Isolated from Cladobotryum sp. No. 11231. Taxonomy of the Producing Organism, Fermentation, Isolation,Physico-chemical Properties and Biological Activities
| Autor: | Shizue Izumi, Tomoko Nakanishi, Masakuni Okuhara, Kazutoshi Sakamoto, Michio Yamashita, Eisaku Tsujii, Fumie Abe, Nobuharu Shigematsu |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_treatment
Biology Lymphocyte Activation Mice chemistry.chemical_compound Organophosphorus Compounds In vivo Drug Discovery medicine Animals Pharmacology Mice Inbred BALB C Immunosuppression Biological activity Phosphate Rats Inbred F344 In vitro Rats Transplantation Biochemistry chemistry Rats Inbred Lew Delayed hypersensitivity Fermentation Mitosporic Fungi Immunosuppressive Agents |
| Zdroj: | The Journal of Antibiotics. 49:37-44 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.49.37 |
| Popis: | FR901483, a novel immunosuppressant, has been isolated from the fermentation broth of Cladobotryum sp. No. 11231. The molecular formula of FR901483 has been determined as C20H31N2O6P. FR901483 exerts a potent immunosuppressive activity in vitro and significantly prolongs graft survival time in the rat skin allograft model. This compound has an intriguing tricyclic structure possessing a phosphate ester in its molecule. The ester residue may play an important role in exerting immunosuppressive activity because the desphosphoryl compound is devoid of activity. It is thought that the primary target of immunosuppression by this compound is inhibition of purine nucleotide biosynthesis. |
| Databáze: | OpenAIRE |
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