Drug resistance: origins, evolution and characterization of genomic clones and the tumor ecosystem to optimize precise individualized therapy
| Autor: | Dimitrios H Roukos, Ioannis D Kyrochristos, Demosthenes E Ziogas |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Drug resistance Computational biology Biology Genome Transcriptome 03 medical and health sciences 0302 clinical medicine Acquired resistance Neoplasms Drug Discovery medicine Animals Humans Precision Medicine Ecosystem Pharmacology Cancer type Cancer Genomics medicine.disease Precision medicine 030104 developmental biology Drug Resistance Neoplasm Tumor progression 030220 oncology & carcinogenesis |
| Zdroj: | Drug Discovery Today. 24:1281-1294 |
| ISSN: | 1359-6446 |
| Popis: | Progress in understanding and overcoming fatal intrinsic and acquired resistance is slow, with only a few exceptions. Despite advances in modern genome and transcriptome analysis, the controversy of the three different theories on drug resistance and tumor progression, namely dynamic intratumor heterogeneity, pre-existing minor genomic clones and tumor ecosystem, is unresolved. Moreover, evidence on transcriptional heterogeneity suggests the necessity of a drug bank for individualized, precise drug-sensitivity prediction. We propose a cancer type- and stage-specific clinicogenomic and tumor ecosystemic concept toward cancer precision medicine, focusing on early therapeutic resistance and relapse. |
| Databáze: | OpenAIRE |
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