Histological Characteristics of the Pelage Skin of Rough fur Mice(C3H/HeJ-ruf/ruf)
| Autor: | Shizu Hayasaka, Yoshiko Takagishi, Sen-ichi Oda, Masaaki Okumoto, Minoru Inouye, Yeong-Gwan Park |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Sebaceous gland
Pathology medicine.medical_specialty Mutant Chromosome 9 Biology Skin Diseases General Biochemistry Genetics and Molecular Biology Mice Sebaceous Glands Animal model Lipid droplet medicine Animals Electron microscopic Skin Mice Inbred C3H Staining and Labeling integumentary system General Veterinary Homozygote General Medicine Lipids Mice Mutant Strains Staining Microscopy Electron medicine.anatomical_structure Mutation lipids (amino acids peptides and proteins) Animal Science and Zoology Hair Diseases Azo Compounds Hair |
| Zdroj: | Experimental Animals. 50:179-182 |
| ISSN: | 1881-7122 1341-1357 |
| DOI: | 10.1538/expanim.50.179 |
| Popis: | Pelage skin of C3H/HeJ mice homozygous at an autosomal recessive mutant locus, rough fur (ruf) which is located on chromosome 9, was histologically analyzed. Sebaceous glands synthesizing lipids were larger in the mutant mice than in controls in an examination by Sudan IV staining. Electron microscopic analysis of the sebaceous gland showed that lipid droplets were denser in mutant mice than in control mice, and that they were irregular in shape in ruf mice while those of controls were round. Our results suggested that rough fur (ruf) mice might be an animal model for hyperlipogenesis of the pelage skin. |
| Databáze: | OpenAIRE |
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