Association of lower nighttime diastolic blood pressure and hypoxia with silent myocardial injury: The Japan Morning Surge‐Home Blood Pressure study
| Autor: | Kazuomi Kario, Satoshi Hoshide, Kana Kubota |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Ambulatory blood pressure Endocrinology Diabetes and Metabolism Ambulatory Blood Pressure nighttime hypoxia Population Diastole Blood Pressure 030204 cardiovascular system & hematology Asymptomatic 03 medical and health sciences 0302 clinical medicine Japan Troponin T cardiovascular disease Risk Factors Internal medicine Natriuretic Peptide Brain Internal Medicine medicine Humans myocardial injury 030212 general & internal medicine education Hypoxia Morning education.field_of_study Original Paper business.industry Odds ratio Hypoxia (medical) Peptide Fragments ambulatory blood pressure monitoring Blood pressure Hypertension Cardiology medicine.symptom Cardiology and Cardiovascular Medicine business Biomarkers nighttime blood pressure |
| Zdroj: | The Journal of Clinical Hypertension |
| ISSN: | 1751-7176 1524-6175 |
| Popis: | Whether marked nocturnal blood pressure (BP) reduction is associated with cardiovascular disease (CVD) is still controversial. In addition, no report has yet discussed the relationship between lower nocturnal BP and CVD, involving modification by nighttime hypoxia. We evaluated 840 patients who had one or more cardiovascular risk factors by measuring their high‐sensitivity cardiac troponin T (Hs‐cTnT), N‐terminal pro‐B‐type natriuretic peptide (NT‐pro BNP), and nighttime saturation levels and performing ambulatory BP monitoring. The lowest tertile in nighttime diastolic BP (DBP) (≤66 mmHg) had increased likelihood of the presence of ≥0.014 ng/ml of Hs‐cTnT compared with the second tertile (odds ratio [OR] 1.91, 95% confidence interval [CI] 1.01–3.63), and the lowest tertile of minimum blood oxygen saturation (≤81%) had increased likelihood of the presence of ≥0.014 ng/ml of Hs‐cTnT compared with the third tertile (OR 2.15, 95% CI 1.13–4.10). Additionally, the patients with both lowest tertile of nighttime DBP and minimum SpO2 showed increased likelihood of the presence of ≥0.014 ng/ml of Hs‐cTnT compared with those without this combination (OR 2.93, 95% CI 1.40–6.16). On the other hand, these associations were not found in the presence of ≥125 pg/ml of NT‐pro BNP. In the clinical population, each of lower nocturnal DBP and nighttime hypoxia was associated with asymptomatic myocardial injury, which was represented as higher Hs‐cTnT, and coexisting lower nocturnal DBP and nighttime hypoxia had an additive effect on the risk of myocardial injury. |
| Databáze: | OpenAIRE |
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