Simultaneous pancreas kidney transplants in diabetic patients with end-stage renal disease: the 20-yr experience

Autor:	Marvin Tucker, Jimmy A. Light
Rok vydání:	2013
Předmět:	Male medicine.medical_specialty medicine.medical_treatment Pancreas transplantation Gastroenterology End stage renal disease Diabetes Complications chemistry.chemical_compound Risk Factors Internal medicine Diabetes mellitus medicine Humans Survival rate Transplantation Kidney C-Peptide C-peptide business.industry Graft Survival Middle Aged Prognosis medicine.disease Surgery Survival Rate Diabetes Mellitus Type 1 medicine.anatomical_structure Diabetes Mellitus Type 2 chemistry Kidney Failure Chronic Female Pancreas Transplantation Age of onset Pancreas business Follow-Up Studies
Zdroj:	Clinical Transplantation. 27:E256-E263
ISSN:	0902-0063
DOI:	10.1111/ctr.12100
Popis:	We are reporting the results over a 20 yr period of simultaneous pancreas-kidney transplants in patients with end-stage renal disease and diabetes mellitus. The outcomes of the transplants, performed between 1989 and 2008, are stratified by pretransplant c-peptide value.One hundred and seventy-three patients with end-stage renal disease due to diabetes, and were stratified according to undetectable c-peptide (x 0.8 ng/mL) and detectable c-peptide (x 0.8 ng/mL) levels.Patients with detectable c-peptide (x 0.8 ng/mL) were the oldest at diabetes diagnosis (24.2 vs. 15.4 yr, p 0.0001), and oldest at transplant (42.8 vs. 38.5, p 0.0001) had fewer years of insulin use (19.19 vs. 22.57 yr, p = 0.012), and were heavier pre transplant (BMI: 26.09 vs. 23.1, p 0.0001), and heavier post transplant (29.8 vs. 24.7, p 0.0001). Those with detectable c-peptide levels (x 0.8 ng/mL) had better graft survival than those with an undetectable c-peptide level (x 0.8 ng/mL), p = 0.064; while those with undetectable levels, had better patient survival than those with detectable c-peptide levels (p = 0.019).Despite the differences between groups by BMI, age of onset of insulin use, and age at transplant, there was a difference in patient but not graft survival within the 20 yr follow-up period.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f47c9ad5f0e6a3c283820063642b68 https://doi.org/10.1111/ctr.12100 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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