Gut microbiota, hypertension and chronic kidney disease: Recent advances
| Autor: | Franco De Michieli, Renato Parente, Berrutti M, Elena Paschetta, Antonio Sircana, Giovanni Musso, L. Framarin, Daria Bongiovanni, Nicola Leone |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Population Disease 030204 cardiovascular system & hematology Gut flora Bioinformatics Pathogenesis 03 medical and health sciences 0302 clinical medicine Immune system medicine Animals Humans Microbiome Renal Insufficiency Chronic education Pharmacology education.field_of_study biology business.industry Probiotics medicine.disease biology.organism_classification Gastrointestinal Microbiome 030104 developmental biology Hypertension Complications of hypertension business Kidney disease |
| Zdroj: | Pharmacological Research. 144:390-408 |
| ISSN: | 1043-6618 |
| DOI: | 10.1016/j.phrs.2018.01.013 |
| Popis: | A large number of different microbial species populates intestine. Extensive research has studied the entire microbial population and their genes (microbiome) by using metagenomics, metatranscriptomics and metabolomic analysis. Studies suggest that the imbalances of the microbial community causes alterations in the intestinal homeostasis, leading to repercussions on other systems: metabolic, nervous, cardiovascular, immune. These studies have also shown that alterations in the structure and function of the gut microbiota play a key role in the pathogenesis and complications of Hypertension (HTN) and Chronic Kidney Disease (CKD). Increased blood pressure (BP) and CKD are two leading risk factors for cardiovascular disease and their treatment represents a challenge for the clinicians. In this Review, we discuss mechanisms whereby gut microbiota (GM) and its metabolites act on downstream cellular targets to contribute to the pathogenesis of HTN and CKD, and potential therapeutic implications. |
| Databáze: | OpenAIRE |
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