Effects of intravenous dexmedetomidine on spinal anesthesia and sedation - A comparison of two different maintenance infusions

Autor:	Pratibha V Toal, Pritee H Bhirud, Shrividya Chellam, Mandar N Mote
Rok vydání:	2020
Předmět:	Sedation lcsh:RS1-441 Hemodynamics Group B lcsh:RD78.3-87.3 lcsh:Pharmacy and materia medica 03 medical and health sciences 0302 clinical medicine Bolus (medicine) 030202 anesthesiology Heart rate medicine Pharmacology (medical) subarachnoid block General Pharmacology Toxicology and Pharmaceutics Dexmedetomidine Letters to Editor business.industry dexmedetomidine Spinal anesthesia 030208 emergency & critical care medicine Anesthesiology and Pain Medicine Mean blood pressure sedation lcsh:Anesthesiology Anesthesia intravenous medicine.symptom business medicine.drug
Zdroj:	Journal of Anaesthesiology, Clinical Pharmacology Journal of Anaesthesiology Clinical Pharmacology, Vol 36, Iss 1, Pp 78-82 (2020)
ISSN:	0970-9185
DOI:	10.4103/joacp.joacp_129_18
Popis:	Background and Aims: Our aim was to study the effects of a low-dose bolus (0.5 mcg/kg) of dexmedetomidine followed by two different infusion doses (0.25, 0.5 mcg/kg/h) on spinal anesthesia, sedation, hemodynamics and side effects. Material and Methods: Eighty consenting patients were randomized into two groups A and B with 40 patients each. Patients in both groups were administered intravenous (IV) dexmedetomidine 0.5 mcg/kg over 10 min prior to SAB followed by IV dexmedetomidine 0.25 mcg/kg/h infusion (A) and 0.5 mcg/kg/h infusion (B) throughout the duration of surgery. Time for onset of sensory and motor block, duration of motor block and analgesia, time for two segment regression, intra operative hemodynamics and sedation were assessed. P value less than 0.05 was taken as significant. Results: Onset of sensory block to T10 was 2.1 ± 0.3 min in group A and group B. Onset of motor block was 4.6 ± 0.9 min in group A and 4.3 ± 0.9 min in group B. Duration of motor block in group A was 235.6 ± 12.4 min compared to group B which was 245.3 ± 9.3 min. Time for 2 segment regression in group A was 139.7 ± 29.7 min compared to group B which was 152.3 ± 18.7 min. Total duration of analgesia was 259.3 ± 92.4 min in group A and 273.8 ± 52.3 min in group B. There was a significant reduction in heart rate and mean blood pressure compared to the baseline within both the groups. Sedation was comparable in both the groups. Conclusion: IV dexmedetomidine bolus of 0.5 mcg/kg prior to subarachnoid block followed by maintenance infusion of 0.5 mcg/kg/h significantly prolonged duration of motor block, time for two segment regression, along with stable hemodynamics and adequate sedation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f3f10daca24bd3bfa807ceb0bdfba7 https://doi.org/10.4103/joacp.joacp_129_18 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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