Effects Of Molybdenum, Silicon And Nickel On alpha1-Adrenoceptor-Induced Constriction Of Rat Isolated Aorta
| Autor: | Yeow Leng Chua, Chen Chen, Dong Ling Liu, Ming Yan, Yean Leng Lim |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Agonist
Silicon Physiology medicine.drug_class chemistry.chemical_element Aorta Thoracic In Vitro Techniques Muscle Smooth Vascular Constriction Nickel Receptors Adrenergic alpha-1 Physiology (medical) medicine.artery medicine Animals Rats Wistar Phenylephrine Molybdenum Pharmacology Aorta Anatomy Rats chemistry medicine.symptom Vasoconstriction Muscle Contraction Nuclear chemistry medicine.drug |
| Zdroj: | Clinical and Experimental Pharmacology and Physiology. 29:395-398 |
| ISSN: | 1440-1681 0305-1870 |
| Popis: | 1. To determine the effects of trace elements on alpha1-adrenoceptor-mediated vasoconstriction, we studied the effects of molybdenum (Mo), silicon (Si) and nickel (Ni) on vasoconstrictor response to an alpha1-adrenoceptor agonist in rat aorta. 2. Cumulative concentration-contraction curves were obtained for phenylephrine (1 nmol/L-10 micromol/L) in the absence and presence of Mo, Si and Ni (0.3, 1 and 3 micromol/L) in rat aorta rings. Increasing the concentration of Mo and Si from 0.3 to 3 micromol/L shifted the cumulative concentration-contraction curve to the right, but did not reduce the maximal contractile response to phenylephrine. In contrast, Ni at 1 and 3 micromol/L shifted the cumulative concentration-contraction curve to the right and, at 3 micromol/L, reduced the maximum contractile response to phenylephrine. 3. We conclude that micromolar concentrations of Mo, Si and Ni affected alpha1-adrenoceptor-induced vasoconstriction and that Ni significantly inhibited the maximal contractile response to phenylephrine in rat isolated aorta. |
| Databáze: | OpenAIRE |
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