Polyclonal and Specific Antibodies Mediate Protective Immunity against Enteric Helminth Infection

Autor: Maaike Stoel, Kathy D. McCoy, Andrew J. Macpherson, Beatrice M. Senn, Rebecca Stettler, Hans C. Oettgen, Nicola L. Harris, Joanna Massacand, Bernhard Odermatt, Patrick Merky, Corinne Schaer, Rolf M. Zinkernagel, Nicolaas A. Bos, Hans Hengartner, Katja Fink
Přispěvatelé: Translational Immunology Groningen (TRIGR)
Rok vydání: 2008
Předmět:
Cancer Research
HOOKWORM INFECTION
MICROBIO
Trichinella spiralis
Antibodies
Helminth
NEMATOSPIROIDES-DUBIUS
TRICHINELLA-SPIRALIS
Microbiology
Parasite load
NEMATODE INFECTION
Mice
03 medical and health sciences
CYTIDINE DEAMINASE AID
0302 clinical medicine
Immunity
Virology
Immunology and Microbiology(all)
parasitic diseases
Parasite Egg Count
Animals
Intestinal Diseases
Parasitic
MOLIMMUNO
Molecular Biology
Strongylida Infections
030304 developmental biology
Mice
Knockout
Nematospiroides dubius
0303 health sciences
biology
biology.organism_classification
Immunoglobulin A
3. Good health
Mice
Inbred C57BL
EPITHELIAL-CELL FUNCTION
Chronic infection
NIPPOSTRONGYLUS-BRASILIENSIS
HELIGMOSOMOIDES-POLYGYRUS
Polyclonal antibodies
Immunoglobulin G
GERMINAL-CENTERS
B-CELLS
Immunology
biology.protein
Parasitology
Heligmosomoides polygyrus
Antibody
030215 immunology
Zdroj: Cell Host & Microbe, 4(4), 362-373. CELL PRESS
ISSN: 1931-3128
DOI: 10.1016/j.chom.2008.08.014
Popis: Anti-helminth immunity involves CD4(+) T cells, yet the precise effector mechanisms responsible for parasite killing or expulsion remain elusive. We now report an essential role for antibodies in mediating immunity against the enteric helminth Heligmosomoides polygyrus (Hp), a natural murine parasite that establishes chronic infection. Polyclonal IgG antibodies, present in naive mice and produced following Hp infection, functioned to limit egg production by adult parasites. Comparatively, affinity-matured parasite-specific IgG and IgA antibodies that developed only after multiple infections were required to prevent adult worm development. These data reveal complementary roles for polyclonal and affinity-matured parasite-specific antibodies in preventing enteric helminth infection by limiting parasite fecundity and providing immune protection against reinfection, respectively. We propose that parasite-induced polyclonal antibodies play a dual role, whereby the parasite is allowed to establish chronicity, while parasite load and spread are limited, likely reflecting the long coevolution of helminth parasites with their hosts.
Databáze: OpenAIRE
Externí odkaz: