Desensitization for sulfasalazine-induced skin rash in a patient with ulcerative colitis
| Autor: | Kazuya Akahoshi, Hajime Nawata, Hiroaki Okabe, Yoshiharu Chijiiwa, Teppei Kabemura, Yasuo Akamine |
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| Rok vydání: | 1994 |
| Předmět: |
Drug
medicine.medical_specialty media_common.quotation_subject medicine.medical_treatment Sulfasalazine Internal medicine medicine Humans Aged media_common Desensitization (medicine) business.industry Gastroenterology Hepatology medicine.disease Rash Dermatology Ulcerative colitis Desensitization Immunologic Itching Colitis Ulcerative Female Drug Eruptions medicine.symptom business Abdominal surgery medicine.drug |
| Zdroj: | Journal of Gastroenterology. 29:772-775 |
| ISSN: | 1435-5922 0944-1174 |
| DOI: | 10.1007/bf02349286 |
| Popis: | A patient with ulcerative colitis developed a sulfasalazine-induced skin allergy manifested by a urticaria rash. The patient underwent drug desensitization. The first desensitization, done according to Holdsworth's protocol, resulted in eruption with itching at a dose of 800 mg. The second desensitization, with Das's protocol, failed to reintroduce the drug because of urticarial eruptions. The third challenge, with a more gradual increase in sulfasalazine dose than that used in Holdsworth's protocol, successfully desensitized the patient. The relationship between the drug and various adverse reactions is reviewed and the desensitization to sulfasalazine is discussed. |
| Databáze: | OpenAIRE |
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