Mycobacterium ulcerans-specific immune response after immunisation with bacillus Calmette-Guérin (BCG) vaccine
| Autor: | Pittet, Laure, Tebruegge, Marc, Dutta, Binita, Donath, Susan, Messina, Nicole, Casalaz, Dan, Hanekom, Willem A, Britton, Warwick J, Robins-Browne, Roy, Curtis, Nigel, Ritz, Nicole, BCG Immune Response Study (BIRS) group |
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| Rok vydání: | 2021 |
| Předmět: |
Buruli ulcer
medicine.medical_treatment 030231 tropical medicine complex mixtures Russia 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system Japan Humans Medicine 030212 general & internal medicine Mycolactone Randomised controlled trial Mycobacterium bovis ddc:618 Mycobacterium ulcerans General Veterinary General Immunology and Microbiology biology business.industry Prevention Australia Immunity Public Health Environmental and Occupational Health Infant biology.organism_classification Acquired immune system medicine.disease 3. Good health Infectious Diseases Cytokine chemistry Immunology BCG Vaccine Molecular Medicine Immunization business Cross-protection BCG vaccine |
| Zdroj: | Vaccine, Vol. 39, No 4 (2021) pp. 652-657 |
| ISSN: | 0264-410X |
| Popis: | Background Bacillus Calmette–Guerin (BCG) vaccine provides partial protection against Buruli ulcer caused by Mycobacterium ulcerans in epidemiological studies. This study aimed to quantify M. ulcerans-specific immune responses induced by BCG immunisation. Methods Intracellular cytokine analysis of in-vitro experiments done 10 weeks after BCG immunisation in 130 Australian infants randomised to one of three BCG vaccine strains given either at birth (BCG-Denmark, BCG-Japan, or BCG-Russia) or at two months of age (BCG-Denmark). Results Proportions of polyfunctional CD4+ T-cells were higher in M. ulcerans-stimulated compared to unstimulated control samples. These proportions were not influenced by the vaccine strain or timing of the immunisation. The M. ulcerans-specific immune responses showed similar patterns to those observed in M. tuberculosis-stimulated samples, although they were of lower magnitude. Conclusions Our data show that BCG immunisation induces M. ulcerans-specific immune responses in infants, likely explaining the cross-protective effect observed in epidemiological studies. (ACTRN12608000227392) |
| Databáze: | OpenAIRE |
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