A composition of bractatin and neobractatin from the fruits of Garcinia bracteata induces apoptosis in throat cancer through the endoplasmic reticulum stress, mitochondrial apoptotic and Akt pathways
| Autor: | Yu Peng, Jingtong Deng, Huiqi Huang, Xiandong Zhou, Tongxi Zhou, Xinzhou Yang, Guangzhong Yang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Nutrition and Dietetics
biology Chemistry Nutrition. Foods and food supply Endoplasmic reticulum Akt Throat Cancer Medicine (miscellaneous) Cancer Prenylxanthone Apoptosis biology.organism_classification medicine.disease In vitro In vivo medicine Cancer research Endoplasmic reticulum stress TX341-641 Garcinia Throat cancer Protein kinase B Food Science Garcinia bracteata |
| Zdroj: | Journal of Functional Foods, Vol 84, Iss, Pp 104585-(2021) |
| ISSN: | 1756-4646 |
| Popis: | Throat cancer is a common head and neck malignant tumor with a relatively high mortality rate. Prenylxanthone, is the major bioactive substance isolated from the genus Garcinia with anti-cancer effects. However, the anti-tumor activity of Prenylxanthone and its molecular mechanism in throat cancer have not been reported yet. In this study, a composition of two prenylxanthones (CPX) from the fruits of Garcinia bracteata was obtained to evaluate its chemical composition, anti-throat cancer ability and underlying mechanism in vitro and in vivo. The data revealed that CPX, composed of bractatin and neobractatin, dose-dependently suppressed throat cancer cells Hep-2 and FaDu proliferation and apoptosis, and inhibited xenografts growth in nude mice without significant toxicity. Furthermore, CPX exerted anti-throat cancer effect by inducing apoptosis through endoplasmic reticulum (ER) stress, mitochondrial apoptotic and Akt pathways. All results suggested that CPX could be considered as a potential chemotherapeutic drug for throat cancer. |
| Databáze: | OpenAIRE |
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