Procalcitonin serum concentration during Pneumocystis jiroveci colonization or Pseudomonas aeruginosa infection/colonization in lung transplant recipients
| Autor: | Marta Szewczyk, E. Kucewicz-Czech, J. Wojarski, M. Siola, M. Zembala, J. Nozynski, S Zeglen, E Wozniak-Grygiel |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Calcitonin Male medicine.medical_specialty Opportunistic infection medicine.medical_treatment Calcitonin Gene-Related Peptide medicine.disease_cause Pneumocystis carinii Gastroenterology Procalcitonin Postoperative Complications Risk Factors Internal medicine parasitic diseases medicine Lung transplantation Pneumocystis jirovecii Humans Colonization Pseudomonas Infections Survivors Protein Precursors Transplantation biology Pseudomonas aeruginosa Pneumonia Pneumocystis Middle Aged medicine.disease biology.organism_classification Survival Analysis Pneumonia Immunology Surgery Female Lung Transplantation |
| Zdroj: | Transplantation proceedings. 41(8) |
| ISSN: | 1873-2623 |
| Popis: | Allograft infection after lung transplantation (OLT) has a significant impact on outcomes and represents a diagnostic challenge. Pneumocystis jirovecii causes an opportunistic infection, life-threatening pneumonia among immunocompromised patients. Airway colonization with Pseudomonas aeruginosa is common in lung transplant recipients. The aim of the study was to evaluate procalcitonin (PCT) serum concentrations during P jiroveci and P aeruginosa colonization/infections in lung transplant recipients.Fifteen OLT patients were retrospectively enrolled into the study (10 men and 5 women) of overall mean age of 41.4 +/- 14.6 years. In seven patients, P jiroveci cysts were diagnosed (group J) and in 13 patients, we isolated P aeruginosa (group A). In respiratory samples, P jiroveci was detected using an indirect immunofluorescence method, and P aeruginosa was isolated using routine microbiologic methods. PCT was measured using immunoluminescence assay.The average PCT value in group A was 0.30 +/- 0.21 and in group J, 0.88 +/- 0.43, a difference that was not significant. In group A, 3 patients (23.1%) has PCT values indicating moderate infection risk (PCT0.5) and one patient (7.7%), a high infection risk (PCT2.0 and10). In group J, three patients (42.9%) has PCT values indicating moderate and one patient (14.3%), high infection risk.Bronchial tree colonization with P jiroveci as well as P aeruginosa colonization can be associated with increased PCT suggesting a general, systemic response in addition to local colonization. |
| Databáze: | OpenAIRE |
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