Multi-Organs-on-Chips for Testing Small-Molecule Drugs: Challenges and Perspectives

Autor:	Leyla Didem Kozaci, Sedef Tamburaci, Mubashir Nazir, Christina Karavasili, Fatemeh Shahriyari, Amir K. Miri, Berivan Cecen, Melda Buyukoz, Anant Bhusal, Elvan Dogan
Přispěvatelé:	İstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, Berivan Çeçen / 0000-0002-0081-2004, Çeçen, Berivan, Berivan Çeçen / Q-4203-2019, Berivan Çeçen / 24461480700
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Drug Computer science media_common.quotation_subject small drugs microfluidics Pharmaceutical Science Review Small molecule high-throughput screening RS1-441 ComputingMethodologies_PATTERNRECOGNITION Pharmacy and materia medica Risk analysis (engineering) multi-organ-on-a-chip media_common
Zdroj:	Pharmaceutics, Vol 13, Iss 1657, p 1657 (2021) Pharmaceutics
ISSN:	1999-4923
Popis:	Organ-on-a-chip technology has been used in testing small-molecule drugs for screening potential therapeutics and regulatory protocols. The technology is expected to boost the development of novel therapies and accelerate the discovery of drug combinations in the coming years. This has led to the development of multi-organ-on-a-chip (MOC) for recapitulating various organs involved in the drug–body interactions. In this review, we discuss the current MOCs used in screening small-molecule drugs and then focus on the dynamic process of drug absorption, distribution, metabolism, and excretion. We also address appropriate materials used for MOCs at low cost and scale-up capacity suitable for high-performance analysis of drugs and commercial high-throughput screening platforms. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. WOS:000714080800001 Q1
Databáze:	OpenAIRE
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