PITUITARY STIMULATION TEST IN AMENORRHOEIC PATIENTS WITH NORMAL OR LOW SERUM OESTRADIOL
| Autor: | Oscar A. Kletzky, Val Davajan, Daniel R. Mishell, John T. Nicoloff, Robert B. Mims, Robert M. Nakamura |
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| Rok vydání: | 1978 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Pituitary Function Tests Hypothalamus Thyrotropin Stimulation Endocrinology Pituitary Gland Anterior Internal medicine Humans Medicine Amenorrhea Thyrotropin-Releasing Hormone Estradiol business.industry General Medicine Luteinizing Hormone Test (assessment) Growth Hormone Female Follicle Stimulating Hormone business Pituitary Hormone-Releasing Hormones hormones hormone substitutes and hormone antagonists |
| Zdroj: | Acta Endocrinologica. 87:456-466 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/acta.0.0870456 |
| Popis: | A group of 15 patients with secondary amenorrhoea were studied. In 8 of these patients (hypothalamic-pituitary dysfunction, HPD) the baseline plasma Oe2 concentration (47.7 ± 6.0 pg ml) was similar to the early follicular phase levels of the 9 control subjects (48.8 ± 3.3 pg/ml). The remaining 7 patients (hypothalamic-pituitary failure, HPF) had significantly lower plasma Oe2 values (19.8 ± 2.6 pg/ml). Plasma LH and FSH levels were similar in the two groups of patients as well as the controls. All patients and control subjects were sequentially stimulated with insulin induced hypoglycaemia, GnRH-TRH and then GnRH alone. Although abnormal GH and PRL responses to hypoglycaemia and blunted PRL responses to TRH were obtained in the two groups of patients the results could not be correlated with plasma Oe2 baseline values. In both groups of patients, cortisol and TSH responses were comparable to the control subjects. Following the administration of GnRH the maximum LH response in patients of the HPF group was significantly lower (P < 0.025) than the LH response in patients of the HPD group. No statistically significant difference was found in the FSH response between the two groups. In conclusion, most of the patients with secondary amenorrhoea due to HPD have been shown to have most probably a hypothalamic derangement. Patients with HPF may have either a more profound hypothalamic involvement or an intrinsic pituitary alteration. |
| Databáze: | OpenAIRE |
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