Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia
| Autor: | Jian-Chao Chen, Lu Lu, Renrong Tian, Ming-Hua Qiu, Zhong-Quan Zhang, Yong-Tang Zheng |
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| Rok vydání: | 2008 |
| Předmět: |
Momordica charantia
Cell Survival Stereochemistry Plant Science Horticulture Cucurbitane Plant Roots Biochemistry Cell Line chemistry.chemical_compound Cucurbitacins Triterpene Humans Glycosides Cytotoxicity Molecular Biology chemistry.chemical_classification Momordica biology Chemistry Biological activity General Medicine biology.organism_classification Triterpenes Terpenoid Cucurbitaceae |
| Zdroj: | Phytochemistry. 69:1043-1048 |
| ISSN: | 0031-9422 |
| DOI: | 10.1016/j.phytochem.2007.10.020 |
| Popis: | Five cucurbitacins, kuguacins A-E (1-5), together with three known analogues, 3 beta,7 beta,25-trihydroxycucurbita-5,(23E)-diene-19-al (6), 3 beta,25-dihydroxy-5 beta,19-epoxycucurbita-6,(23E)-diene (7), and momordicine I (8), were isolated from roots of Momordica charantia. Structures of 1-5 were elucidated by NMR and MS spectroscopic analysis. Among them, compounds 3-5 possess an unprecedented 25,26,27-trinorcucurbitane backbone. Compounds 3 and 5 showed moderate anti-HIV-1 activity with EC(50) values of 8.45 and 25.62 mu g/ml, and exerted minimal cytotoxicity against C8166 cells (IC(50) > 200 mu g/ml), with a selectivity index more than 23.68 and 7.81, respectively. (C) 2007 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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