Utility of diffusion weighted imaging with the quantitative apparent diffusion coefficient in diagnosing residual or recurrent hepatocellular carcinoma after transarterial chemoembolization: a meta-analysis

Autor: Chen He, Jin-Ming Fan, Zhao Liu, Zhi-Fan Li, Zhao Li, Jun-Qiang Lei, Hai-Feng Liu, Yong-Sheng Xu
Jazyk: angličtina
Rok vydání: 2020
Předmět:
lcsh:Medical physics. Medical radiology. Nuclear medicine
medicine.medical_specialty
Residual Tumors
Carcinoma
Hepatocellular
Apparent diffusion coefficient (ADC)
lcsh:R895-920
Cochrane Library
Residual
Sensitivity and Specificity
lcsh:RC254-282
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Medicine
Effective diffusion coefficient
Humans
Radiology
Nuclear Medicine and imaging
Chemoembolization
Therapeutic
Hepatocellular carcinoma (HCC)
Methodological quality
Diffusion weighted imaging (DWI)
Radiological and Ultrasound Technology
business.industry
Liver Neoplasms
General Medicine
Transarterial chemoembolization (TACE)
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Recurrent Hepatocellular Carcinoma
Meta-analysis
Diffusion Magnetic Resonance Imaging
Oncology
030220 oncology & carcinogenesis
Radiology
Neoplasm Recurrence
Local
business
Diffusion MRI
Research Article
Zdroj: Cancer Imaging, Vol 20, Iss 1, Pp 1-10 (2020)
Cancer Imaging
ISSN: 1470-7330
Popis: Background Accurate and early diagnosis of residual tumors or intrahepatic recurrences after TACE is critically needed for determining the success of treatments and for guiding subsequent therapeutic planning. This meta-analysis was performed to assess the efficacy of diffusion weighted imaging (DWI) with the quantitative apparent diffusion coefficient (ADC) value in diagnosing residual or recurrent hepatocellular carcinoma after transarterial chemoembolization (TACE). Materials and methods A comprehensive literature search of PubMed, Embase, Web of Science, Scopus and the Cochrane Library database, from inception to July 2019, was conducted to select original studies on diagnosing residual or recurrent HCCs after TACE using DWI sequence with its ADC value. Two researchers independently chose study, extracted data, conducted meta-analysis, and evaluated methodological quality according to Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool. Results Twelve studies comprising 624 patients and 712 tumors were finally included. The pooled sensitivity, specificity and AUC value of DWI in diagnosing residual or recurrent HCCs after TACE were 85% (95%CI: 74–92%), 83% (95%CI: 75–88%) and 0.90 (95%CI: 0.87–0.92), respectively. Residual or recurrent HCCs have significantly lower ADC value than necrotic tumors (MD = -0.48, 95%CI: − 0.69~ − 0.27, P Conclusion This study demonstrated that DWI performed better in diagnosing residual or recurrent HCCs after TACE, and ADC value may serve as alternatives for further evaluation of residual or recurrent leisions in HCC patients after TACE.
Databáze: OpenAIRE
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