Computed Tomography Cholangiography Using the Magnetic Resonance Contrast Agent Gadoxetate Disodium: A Phantom Study
| Autor: | Sudhakar K. Venkatesh, Jeff L. Fidler, Noelle Nelson, Samantha K N Dilger, Eric C. Ehman, Cynthia H. McCollough, Lifeng Yu, Joel G. Fletcher |
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| Rok vydání: | 2019 |
| Předmět: |
Gadolinium DTPA
Materials science Gadolinium media_common.quotation_subject chemistry.chemical_element Contrast Media Signal-To-Noise Ratio Imaging phantom 030218 nuclear medicine & medical imaging Gadoxetate Disodium 03 medical and health sciences 0302 clinical medicine Cholangiography Iodipamide Meglumine medicine Contrast (vision) Humans Radiology Nuclear Medicine and imaging media_common Retrospective Studies medicine.diagnostic_test business.industry Phantoms Imaging Magnetic resonance imaging General Medicine Image Enhancement Intensity (physics) chemistry Nuclear medicine business Tomography X-Ray Computed 030217 neurology & neurosurgery |
| Zdroj: | Investigative radiology. 54(9) |
| ISSN: | 1536-0210 |
| Popis: | OBJECTIVE The purpose of this work is to determine whether low doses of gadoxetate disodium (Eovist; Bayer Healthcare LLC, Whippany, NJ), a gadolinium-based contrast agent used for magnetic resonance liver imaging, can be visualized for computed tomography (CT) cholangiography using a phantom setup. MATERIALS AND METHODS Vials containing 4 concentrations of gadoxetate disodium (1.9, 3.4, 4.8, and 9.6 mg Gd/mL) were placed in a 35 × 26-cm water phantom and imaged on 2 CT scanners: Siemens Somatom Flash and Force (Siemens Healthcare, Erlangen, Germany). These concentrations correspond to the estimated concentration in the bile duct for a 40-, 70-, or 100-kg patient, and twice the concentration of a 100-kg patient, respectively. Single-energy (SE) scans were acquired at 70, 80, 90, 100, 120, and 140 kVp, and dual-energy scans were acquired at 90/150Sn (Force) and 100/150 (Flash) for 2 dose levels (CTDIvol 13 and 23 mGy). Virtual monoenergetic images at 50 keV were created (Mono+; Siemens Healthcare, Erlangen, Germany). The mean intensity and standard deviation for each concentration of gadoxetate disodium and the water background were extracted from each image set and used to compute the contrast and contrast-to-noise ratio (CNR). To determine whether the signal provided by gadoxetate disodium was clinically sufficient, the measures were compared with those acquired from 12 clinical CT cholangiography examinations performed with iodine-containing iodipamide meglumine. RESULTS From the retrospective clinical cohort, mean contrast (± standard deviation) of 239 ± 107 HU and CNR of 12.8 ± 4.2 were found in the bile duct relative to the liver. Comparing these metrics to the gadoxetate disodium samples, the highest concentration (9.6 mg Gd/mL) surpassed these thresholds at all energy levels. The 4.8 mg Gd/mL had sufficient CNR in the Force, but not in the Flash. The 3.4 mg Gd/mL had clinically relevant CNR at low kV of SE ( |
| Databáze: | OpenAIRE |
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