Paraventricular hypothalamic α-melanocyte-stimulating hormone and MTII reduce feeding without causing aversive effects
| Autor: | Pawel K. Olszewski, Carolyn Yu, Allen S. Levine, Michelle M. Wirth, Silvia Q. Giraudo |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Agonist endocrine system medicine.medical_specialty Melanocyte-stimulating hormone Physiology medicine.drug_class Hypothalamus Inhibitory postsynaptic potential Biochemistry Rats Sprague-Dawley Eating Cellular and Molecular Neuroscience Endocrinology Internal medicine medicine Animals Receptor Melanocortins Chemistry digestive oral and skin physiology Rats Receptors Corticotropin alpha-MSH Taste aversion Receptor Melanocortin Type 4 Melanocortin hormones hormone substitutes and hormone antagonists Receptor Melanocortin Type 3 Hormone |
| Zdroj: | Peptides. 22:129-134 |
| ISSN: | 0196-9781 |
| Popis: | alpha-Melanocyte-stimulating hormone (alpha-MSH) appears to play a tonic inhibitory role in feeding and energy storage. MTII, a specific synthetic MC3-R/MC4-R agonist, has similar effects on feeding in rats. The current studies demonstrate that PVN administration of alpha-MSH or MTII decreases nocturnal and NPY-stimulated food intake without causing aversive effects. Co-administration with NPY of 600 pmol alpha-MSH or 1 pmol MTII into the PVN caused a significant decrease in NPY-induced feeding. PVN administration of MTII or alpha-MSH at doses effective to suppress feeding did not cause conditioned taste aversion (CTA). ICV administration of alpha-MSH, however, did cause weak CTA. These results indicate that the potent effects on feeding of MC3-R and MC4-R agonists when injected into the PVN are not due to aversive effects. |
| Databáze: | OpenAIRE |
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