Application of Tethered Ruthenium Catalysts to Asymmetric Hydrogenation of Ketones, and the Selective Hydrogenation of Aldehydes

Autor:	Alan Dyke, Jacques Le Paih, Fred Hancock, Damian M. Grainger, Vilvanathan Sivakumar, Stephen Roseblade, Antonio Zanotti-Gerosa, Katherine E. Jolley, Hans Günter Nedden, Jonathan Medlock, Ivan Prokes, Andreas Seger, Martin Wills, David J. Morris
Rok vydání:	2012
Předmět:	chemistry.chemical_classification Ketone Asymmetric hydrogenation Enantioselective synthesis Noyori asymmetric hydrogenation chemistry.chemical_element General Chemistry Aldehyde Ruthenium Catalysis chemistry Organic chemistry QD Enantiomeric excess
Zdroj:	Advanced Synthesis & Catalysis. 354:2545-2555
ISSN:	1615-4169 1615-4150
DOI:	10.1002/adsc.201200362
Popis:	An improved method for the synthesis of tethered ruthenium(II) complexes of monosulfonylated diamines is described, together with their application to the hydrogenation of ketones and aldehydes. The complexes were applied directly, in their chloride form, to asymmetric ketone hydrogenation, to give products in excess of 99% ee in the best cases, using 30 bar of hydrogen at 60 °C, and to the selective reduction of aldehydes over other functional groups.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e2c88e7d2a65db1c4473059c8ed381 https://doi.org/10.1002/adsc.201200362 Zobrazit plný text záznamu Plný text ve formátu PDF