| Autor: |
Wang, Xin, Li, You, Vazquez Fernandez, Liliana, Teirlinck, Anne C, Lehtonen, Toni, van Wijhe, Maarten, Stona, Luca, Bangert, Mathieu, Reeves, Rachel M, Bøås, Håkon, van Boven, Michiel, Heikkinen, Terho, Klint Johannesen, Caroline, Baraldi, Eugenio, Donà, Daniele, Tong, Sabine, Campbell, Harry, Nair, Harish, Fischer, Thea Kølsen, Simonsen, Lone, Trebbien, Ramona, Johannesen, Caroline Klint, Demont, Clarisse, van der Hoek, Wim, van der Maas, Nicoline, Meijer, Adam, Fernandez, Liliana Vazquez, Bekkevold, Terese, Flem, Elmira, Speltra, Irene, Giaquinto, Carlo, Cheret, Arnaud, Leach, Amanda, Stoszek, Sonia, Beutels, Philippe, Bont, Louis, Pollard, Andrew, Openshaw, Peter, Abram, Michael, Swanson, Kena, Rosen, Brian, Molero, Eva |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Popis: |
Background Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infections (RTIs) in young children. High-quality country-specific estimates of bed days and length of stay (LOS) show the population burden of RSV-RTI on secondary care services and the burden among patients, and can be used to inform RSV immunization implementation decisions. Methods We estimated the hospital burden of RSV-associated RTI (RSV-RTI) in children under 5 years in 7 European countries (Finland, Denmark, Norway, Scotland, England, the Netherlands, and Italy) using routinely collected hospital databases during 2001–2018. We described RSV-RTI admission rates during the first year of life by birth month and assessed their correlation with RSV seasonality in 5 of the countries (except for England and Italy). We estimated average annual numbers and rates of bed days for RSV-RTI and other-pathogen RTI, as well as the hospital LOS. Results We found that infants born 2 months before the peak month of RSV epidemics more frequently had the highest RSV-RTI hospital admission rate. RSV-RTI hospital episodes accounted for 9.9–21.2 bed days per 1000 children aged Conclusions RSV disease prevention therapies (monoclonal antibodies and maternal vaccines) for infants could help prevent a substantial number of bed days due to RSV-RTI. "High-risk" birth months should be considered when developing RSV immunization schedules. Variation in LOS between countries might reflect differences in hospital care practices. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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