Growth hormone co-treatment within a GnRH agonist long protocol in patients with poor ovarian response: a prospective, randomized, clinical trial
| Autor: | Tansu Küçük, Hakan Kozinoglu, Ayten Kaba |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Physiology Controlled ovarian hyperstimulation Gonadotropin-releasing hormone Luteal phase law.invention Gonadotropin-Releasing Hormone Ovulation Induction Randomized controlled trial Pregnancy law Genetics medicine Humans Longitudinal Studies Prospective Studies Genetics (clinical) Gynecology Triptorelin Pamoate Human Growth Hormone business.industry Ovary Obstetrics and Gynecology General Medicine medicine.disease Pregnancy rate Treatment Outcome Assisted Reproduction Reproductive Medicine Drug Therapy Combination Female Ovulation induction Gonadotropin business Developmental Biology |
| Zdroj: | Journal of Assisted Reproduction and Genetics. 25:123-127 |
| ISSN: | 1573-7330 1058-0468 |
| DOI: | 10.1007/s10815-008-9212-7 |
| Popis: | The efficacy of growth hormone co-stimulation to long luteal GnRHa regimen in poor responders to COH for IVF was assessed. This prospective, randomized, clinical trial was performed in a private assisted reproduction center. The study involved 61 patients who responded poorly to high dose gonadotropin treatment in their first cycles in the same center. Study group of 31 patients were given growth hormone co-treatment, daily subcutaneous injection of 4 mg from day 21 of preceding cycle along with GnRHa, until the day of hCG. Control group of 30 patients received the same treatment protocol except the growth hormone co-treatment. Primary end-point of the study was the number of oocytes fertilized whereas the pregnancy rate was the secondary end-point. Patients’ demographic characteristics did not differ significantly between the two groups. 2PNs in growth hormone co-treatment group was significantly higher than the control group (4.4 ± 1.8 vs 1.5 ± 0.9, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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