Leptin links with plasminogen activator inhibitor-1 in human obesity: the SABPA study
| Autor: | Chiné Pieterse, Rudolph Schutte, Aletta E. Schutte |
|---|---|
| Přispěvatelé: | 20684444 - Pieterse, Chiné, 10922180 - Schutte, Aletta Elisabeth, 12201405 - Schutte, Rudolph |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Leptin Male medicine.medical_specialty obesity Ambulatory blood pressure Physiology Population Blood Pressure Fibrinogen leptin chemistry.chemical_compound South Africa Internal medicine vascular damage Plasminogen Activator Inhibitor 1 von Willebrand Factor Internal Medicine medicine Ethnicity Albuminuria Humans Obesity education Life Style education.field_of_study business.industry Vascular disease Hemodynamics Middle Aged medicine.disease Body Height Endocrinology Blood pressure chemistry Plasminogen activator inhibitor-1 Creatinine Body Composition Female Waist Circumference Cardiology and Cardiovascular Medicine business Plasminogen activator medicine.drug |
| Zdroj: | Hypertension research : official journal of the Japanese Society of Hypertension. 38(7) |
| ISSN: | 1348-4214 |
| Popis: | The relationship between obesity and the development of cardiovascular disease is well established. However, the underlying mechanisms contributing to vascular disease and increased cardiovascular risk in the obese remain largely unexplored. Since leptin exerts direct vascular effects, we investigated leptin and the relationship thereof with circulating markers of vascular damage, namely plasminogen activator inhibitor-1 antigen (PAI-1(ag)), von Willebrand factor antigen (vWF(ag)) and urinary albumin-to-creatinine ratio (ACR). The study included a bi-ethnic population of 409 African and Caucasian teachers who were stratified into lean ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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