Periprocedural Changes of NT‐proBNP Are Associated With Survival After Transcatheter Aortic Valve Implantation

Autor: Georg Lutter, Hatim Seoudy, Markus Neu, Nathalie Güßefeld, Johanne Frank, Sandra Freitag-Wolf, Christian Kuhn, Ashraf Yusuf Rangrez, Astrid Dempfle, Derk Frank, Moritz Lambers, Norbert Frey, Yannic Klaus
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
medicine.medical_specialty
Transcatheter aortic
Cardiovascular biomarkers
Aortic Valve Replacement/Transcather Aortic Valve Implantation
risk stratification
030204 cardiovascular system & hematology
NT‐proBNP
Transcatheter Aortic Valve Replacement
03 medical and health sciences
0302 clinical medicine
Catheter-Based Coronary and Valvular Interventions
Internal medicine
Germany
Natriuretic Peptide
Brain
medicine
Humans
In patient
030212 general & internal medicine
Protein Precursors
transcatheter aortic valve implantation
Original Research
Aged
Retrospective Studies
Aged
80 and over
business.industry
aortic stenosis
Aortic Valve Stenosis
Peptide Fragments
Survival Rate
Valvular Heart Disease
Aortic Valve
Risk stratification
Preoperative Period
Cardiology
Biomarker (medicine)
biomarker
Female
Cardiology and Cardiovascular Medicine
business
Biomarkers
Follow-Up Studies
Zdroj: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
ISSN: 2047-9980
Popis: Background Cardiovascular biomarkers constitute promising tools for improved risk stratification and prediction of outcome in patients undergoing transcatheter aortic valve implantation. We examined the association of periprocedural changes of NT‐proBNP (N‐terminal pro–B‐type natriuretic peptide) with survival after transcatheter aortic valve implantation. Methods and Results NT‐proBNP levels were measured in 704 patients before transcatheter aortic valve implantation and at discharge. Patients were grouped as responders and nonresponders depending on an NT‐proBNP–based ratio (postprocedural NT‐proBNP at discharge/preprocedural NT‐proBNP). Overall, 376 of 704 patients showed a postprocedural decrease in NT‐proBNP levels (NT‐proBNP ratio P P P =0.042), arterial hypertension (94.2% versus 87.5%, P =0.002), renal impairment (77.4% versus 69.1%, P =0.013), and peripheral artery disease (24.4% versus 14.6%, P =0.001). In contrast, patients in the responder group had higher prevalence of moderately reduced left ventricular ejection fraction (17.3% versus 11.0%, P =0.017), lower calculated aortic valve area (0.7 versus 0.8 cm 2 , P P P Conclusions A ratio based on periprocedural changes of NT‐proBNP is a simple tool for better risk stratification and is associated with survival in patients after transcatheter aortic valve implantation.
Databáze: OpenAIRE
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