The potential of tissue engineering in orthopedics
| Autor: | Jennifer Hillyer, Noritaka Isogai, Lorraine M. Siperko, Susan Chubinskaya, Shinichi Asamura, Robin Jacquet, Jean Zhang, William J. Landis |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Bioprosthesis
musculoskeletal diseases medicine.medical_specialty Tissue Engineering business.industry Cartilage Artificial Limbs Artificial limbs Tendon Fingers Tendons Mice Orthopedics medicine.anatomical_structure Tissue engineering Finger Joint Periosteum Orthopedic surgery medicine Animals Humans Orthopedics and Sports Medicine business Biomedical engineering |
| Zdroj: | Orthopedic Clinics of North America. 36:97-104 |
| ISSN: | 0030-5898 |
| DOI: | 10.1016/j.ocl.2004.06.006 |
| Popis: | This article presents models of human phalanges and small joints developed by tissue engineering. Biodegradable polymer scaffolds support growth of osteoblasts, chondrocytes, and tenocytes after implantation of the models in athymic mice. The cell-polymer constructs are vascularized by the host mice, form new bone, cartilage, and tendon with characteristic gene expression and protein synthesis and secretion, and maintain the shape of human phalanges with joints. The study demonstrates critical progress in the design and fabrication of bone, cartilage, and tendon by tissue engineering and the potential of this field for human clinical orthopedic applications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|