RNA modifications and structures cooperate to guide RNA–protein interactions
| Autor: | Auinash Kalsotra, Cole J.T. Lewis, Tao Pan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Riboswitch RNA-induced transcriptional silencing RNA Stability Computational biology Article 03 medical and health sciences 0302 clinical medicine Protein Splicing RNA Messenger Molecular Biology Genetics Chemistry Intron Proteins RNA Cell Biology Non-coding RNA RNA silencing 030104 developmental biology RNA editing Protein Biosynthesis Nucleic Acid Conformation 030217 neurology & neurosurgery Small nuclear RNA RNA Guide Kinetoplastida |
| Zdroj: | Nature Reviews Molecular Cell Biology. 18:202-210 |
| ISSN: | 1471-0080 1471-0072 |
| DOI: | 10.1038/nrm.2016.163 |
| Popis: | An emerging body of evidence indicates that post-transcriptional gene regulation not only relies on the linear sequence of messenger RNAs but also on their folding into intricate secondary structures and on chemical modification of the RNA bases. These features, which are highly dynamic and interdependent, exert direct control over the transcriptome thereby influencing many aspects of cell function. Here, we consider that coupling of RNA modifications and structure actively shapes RNA-protein interactions through individual steps of gene expression. |
| Databáze: | OpenAIRE |
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