Strategies and Challenges to Myocardial Replacement Therapy
Autor: | Milica Radisic, Nicole Feric |
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Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Heart disease Heart Diseases medicine.medical_treatment Suspension culture Regenerative medicine 03 medical and health sciences Cell injection Internal medicine medicine Animals Humans Myocytes Cardiac Myocardial infarction Heart transplantation Tissue Engineering business.industry Regeneration (biology) Myocardium Cell Biology General Medicine medicine.disease 3. Good health 030104 developmental biology Heart failure Cardiology Heart Transplantation business Developmental Biology Perspectives |
Zdroj: | Stem Cells Translational Medicine |
ISSN: | 2157-6580 2157-6564 |
Popis: | Cardiac cell-based regenerative therapies include application of a cell suspension and the implantation of an in vitro engineered tissue construct to the damaged area of the heart. Both strategies have their advantages and challenges. This review discusses the current state of the art in myocardial regeneration, the challenges to success, and the future direction of the field. Summary Cardiovascular diseases account for the majority of deaths globally and are a significant drain on economic resources. Although heart transplants and left-ventricle assist devices are the solution for some, the best chance for many patients who suffer because of a myocardial infarction, heart failure, or a congenital heart disease may be cell-based regenerative therapies. Such therapies can be divided into two categories: the application of a cell suspension and the implantation of an in vitro engineered tissue construct to the damaged area of the heart. Both strategies have their advantages and challenges, and in this review, we discuss the current state of the art in myocardial regeneration, the challenges to success, and the future direction of the field. Significance This article outlines the advantages and limitations of the cell injection and patch approaches to cardiac regenerative therapy. If the field is to move forward, some fundamental questions require answers, including the limitations to the use of animal models for human cell-transplantation studies; the best way to measure success in terms of functional improvements, histological integration, electrical coupling, and arrhythmias; and where the cells should be applied for maximal benefit—the epicardium or the myocardium. |
Databáze: | OpenAIRE |
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