A pH-responsive stellate mesoporous silica based nanophotosensitizer for in vivo cancer diagnosis and targeted photodynamic therapy
| Autor: | Mei-Rong Ke, Cai-Hong Xu, Jun-Jie Gu, Ai-Lan Lin, Song-Zi Li, Jian-Dong Huang, Xingshu Li, Bi-Yuan Zheng |
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| Rok vydání: | 2018 |
| Předmět: |
Indoles
medicine.medical_treatment Biomedical Engineering Photodynamic therapy 02 engineering and technology Nanoconjugates Isoindoles 010402 general chemistry 01 natural sciences chemistry.chemical_compound Mice In vivo Neoplasms medicine Organometallic Compounds Animals Humans General Materials Science Photosensitizer Photosensitizing Agents Singlet oxygen Optical Imaging Cancer Mesoporous silica Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology medicine.disease Silicon Dioxide 0104 chemical sciences Rats chemistry Photochemotherapy Zinc Compounds Delayed-Action Preparations Biophysics Phthalocyanine Female 0210 nano-technology Porosity Conjugate HeLa Cells |
| Zdroj: | Biomaterials science. 7(1) |
| ISSN: | 2047-4849 |
| Popis: | Development of a photosensitizer that can achieve tumor specificity, improve therapeutic efficacy, and reduce side effects remains a challenge for photodynamic therapy (PDT). In this work, a pH-sensitive activatable nanophotosensitizer (SMSN–ZnPc1) has been elaborately designed, which could be readily prepared by using a functionalized zinc(II) phthalocyanine (ZnPc) to conjugate with stellate mesoporous silica nanoparticles (SMSNs) through an acid-sensitive hydrazone bond. Meanwhile, a non-activatable analogue SMSN–ZnPc2 has also been prepared as a negative control. The fluorescence emission and singlet oxygen generation of the photosensitizer are essentially quenched in the intact nanophotosensitizer. However, these properties of SMSN–ZnPc1 can be restored greatly both in acidic solutions and at the cellular level. More importantly, after intravenous administration, SMSN–ZnPc1 can also be selectively activated at the tumor site and exhibit efficient tumor growth inhibition in S180 rat ascitic tumor-bearing KM mice with negligible systemic toxicity. It thus may serve as a promising nanoplatform for cancer diagnosis and targeted PDT. |
| Databáze: | OpenAIRE |
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