Netherton Syndrome: A Case Report and Review of Literature
| Autor: | Muhammad Faizan Shahid, Atif Sohail, Amir Shahbaz, Muhammad Arslan Shahid, Hafiz M. Kashif Saleem, Issac Sachmechi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Congenital ichthyosiform erythroderma Dermatology Pediatrics ichthyosiform erythroderma 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine netherton syndrome 030225 pediatrics Ichthyosis linearis circumflexa Dry skin medicine Genetics Netherton syndrome Genetic testing medicine.diagnostic_test integumentary system atopic dermatitis business.industry General Engineering Atopic dermatitis medicine.disease body regions trichorrhexis invaginata Differential diagnosis medicine.symptom business Trichorrhexis invaginata |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| Popis: | Netherton syndrome (NS) is a rare autosomal recessive disorder characterized by a triad of congenital ichthyosiform erythroderma (CIE) or ichthyosis linearis circumflexa (ILC), hair shaft abnormalities, and atopic diathesis (elevated serum IgE ). We report a case of a two-year-old boy presented with intractable pruritus, scaling, dry skin and generalized eczematous lesions resistant to atopic dermatitis therapy. Netherton syndrome misdiagnosed as atopic dermatitis due to the presence of eczematous skin lesions and allergic problems. The family counseled about the diagnosis and need of genetic testing for confirmation, but they refused for genetic testing. The patient got treatment with topical corticosteroids and skin moisturizers. There is no cure or satisfactory treatment currently available for NS. Further understanding of the underlying pathophysiology of integumentary changes will lead to more effective treatment. Netherton syndrome should be in the differential diagnosis when characteristic skin manifestation of CIE or ILC, and elevated serum IgE present. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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