How should a positive PCR test result for COVID-19 in an asymptomatic individual be interpreted and managed?
| Autor: | M. Blot, F. Catherine, Lionel Piroth, P. Chavanet, C. Esteve |
|---|---|
| Přispěvatelé: | Département d'infectiologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon) |
| Rok vydání: | 2020 |
| Předmět: |
Pediatrics
medicine.medical_specialty [SDV]Life Sciences [q-bio] Pneumonia Viral Context (language use) Review Polymerase Chain Reaction Asymptomatic Serology Diagnosis Differential Betacoronavirus 03 medical and health sciences COVID-19 Testing Pandemic medicine False positive paradox Humans False Positive Reactions Asymptomatic Infections Pandemics 0303 health sciences Clinical Laboratory Techniques SARS-CoV-2 030306 microbiology Transmission (medicine) business.industry Public health COVID-19 3. Good health Test (assessment) Infectious Diseases medicine.symptom Coronavirus Infections business |
| Zdroj: | Médecine et Maladies Infectieuses Médecine et Maladies Infectieuses, Elsevier Masson, 2020, 50, pp.633-638. ⟨10.1016/j.medmal.2020.09.014⟩ Medecine et Maladies Infectieuses |
| ISSN: | 0399-077X |
| DOI: | 10.1016/j.medmal.2020.09.014 |
| Popis: | The rapidly increasing number of PCR-based SARS-CoV-2 tests as COVID-19 control measures has been leading not only to the discovery of positive results in asymptomatic individuals, but also to the re-testing of persons having contracted (proven or unproven) COVID-19 or having previously tested positive. In the face of interrogations as to the interpretation and management of these types of situations, and given the need to weigh collective and individual risks, we have carried out a review of the literature aimed at responding to the six following questions. Can PCR-based SARS-CoV-2 testing lead to false positives? For how long do the results remain positive? For how long can the results be associated with an actual risk of transmission / with infectivity in a symptomatic person? Is a newly positive PCR-based SARS-CoV-2 test result following one or more negative test results to be associated with a risk of transmission? Is a positive PCR-based SARS CoV-2 test result to be associated with a genuine risk of transmission / with infectivity in an asymptomatic person? Does the presence of antibodies detected by serology attest to control of the infection and consequently to non-contagiousness, even in the event of positive PCR-based SARS-CoV-2 test results? Having been initiated prior to the recently issued recommendations of the Haut Conseil de la Sante Publique (French public health council), this review is aimed at synthesizing practical proposals liable to evolve according to the advancement of scientific knowledge and the overall epidemic context. |
| Databáze: | OpenAIRE |
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