Increased rate of venous thrombosis may be associated with inpatient dihydroergotamine treatment
| Autor: | Amy R. Tso, Amy A. Gelfand, Peter J. Goadsby, Irene Patniyot |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Adolescent Lidocaine 030204 cardiovascular system & hematology Dihydroergotamine Peripherally inserted central catheter Article Tertiary Care Centers Young Adult 03 medical and health sciences symbols.namesake Catheters Indwelling 0302 clinical medicine medicine Humans Child Fisher's exact test Aged Retrospective Studies Venous Thrombosis Inpatients business.industry Incidence Retrospective cohort study Analgesics Non-Narcotic Middle Aged medicine.disease Pulmonary embolism Venous thrombosis Catheter Anesthesia Multivariate Analysis symbols Administration Intravenous Female Neurology (clinical) business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neurology. 89:279-283 |
| ISSN: | 1526-632X 0028-3878 |
| Popis: | Objective:To review whether the incidence of catheter-associated venous thromboses was higher in patients receiving IV dihydroergotamine compared to lidocaine.Methods:We retrospectively reviewed all admissions at the University of California, San Francisco Headache Center from February 25, 2008, through October 31, 2014, for age, sex, diagnosis, aura, treatment dose, type of IV line used, days with line, superficial (SVT) or deep venous thrombosis (DVT), and pulmonary embolism (PE).Results:A peripherally inserted central catheter (PICC) or midline catheter was placed in 315 of 589 (53%) admissions. Mean age was 38 years with a range of 6 to 79 years; 121 patients (21%) were ≤18 years old. Seventy-four percent (433 of 589) of patients were female. Of 263 dihydroergotamine admissions using a PICC or midline catheter, 19 (7.2%) had either an SVT or DVT or a PE; 2 patients were diagnosed with both DVT and PE. Of 52 lidocaine admissions using a PICC or midline catheter, none had a thrombotic event (p = 0.05, Fisher exact test). Age, sex, aura, total dihydroergotamine dose, and number of days with line were not significant predictors of venous thrombosis.Conclusions:IV dihydroergotamine treatment may be associated with an increased risk of catheter-associated venous thrombosis. A low threshold for diagnostic ultrasound investigation is appropriate because anticoagulation therapy was frequently required. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|