Increased Expression of the Retinoblastoma Gene in Human Colorectal Carcinomas Relative to Normal Colonic Mucosa
| Autor: | Mark A. Christensen, Mohan L. Gope, Rajalakshmi Gope, Henry T. Lynch, Thomas C. Smyrk, B. M. Boman, Alan G. Thorson, David M. Wildrick, Clague P. Hodgson |
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| Rok vydání: | 1990 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Biology Retinoblastoma Protein Intestinal mucosa Gene duplication medicine Humans RNA Messenger Copy-number variation Intestinal Mucosa Gene Chromosome 13 Southern blot Retinoblastoma Carcinoma Gene Amplification Retinoblastoma protein Blotting Northern Phosphoproteins medicine.disease Gene Expression Regulation Neoplastic Blotting Southern Genes Oncology Cancer research biology.protein Colorectal Neoplasms DNA Probes |
| Zdroj: | JNCI Journal of the National Cancer Institute. 82:310-314 |
| ISSN: | 1460-2105 0027-8874 |
| DOI: | 10.1093/jnci/82.4.310 |
| Popis: | We report the first evidence of increased levels of the retinoblastoma (Rb) message in a majority of colorectal cancers when compared with normal mucosa. Southern blot analysis showed an increase in Rb gene copy number in at least 28% of colorectal carcinomas relative to normal mucosa. These results plus previous reports of nonrandom chromosome 13 gains in approximately 50% of colorectal cancers suggest that an increase in Rb gene copy number occurs frequently in these tumors. Possible mechanisms pertaining to overexpression of the Rb gene are discussed in relation to its role as a recessive cancer gene. |
| Databáze: | OpenAIRE |
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