Co-Circulation of Two Independent Clades and Persistence of CHIKV-ECSA Genotype during Epidemic Waves in Rio de Janeiro, Southeast Brazil
Autor: | Carolina Cardoso dos Santos, Cintia Damasceno dos Santos Rodrigues, Luiz Carlos Junior Alcantara, Guilherme Amaral Calvet, Maria Celeste Torres, Vagner Fonseca, Marta Giovanetti, Ana Maria Bispo de Filippis, Nieli Rodrigues da Costa Faria, Patrícia Brasil, Simone Alves Sampaio, Allison Fabri, Flávia Löwen Levy Chalhoub, Fernanda de Bruycker-Nogueira |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Microbiology (medical) 030231 tropical medicine lcsh:Medicine Biology Arbovirus Virus Persistence (computer science) 03 medical and health sciences 0302 clinical medicine Genotype medicine Immunology and Allergy Clade Molecular Biology Genetic diversity chikungunya virus General Immunology and Microbiology Phylogenetic tree Transmission (medicine) Brief Report lcsh:R virus diseases persistence medicine.disease 030104 developmental biology Infectious Diseases Evolutionary biology rio de janeiro ECSA genotype Brazil co-circulation |
Zdroj: | Pathogens, Vol 9, Iss 984, p 984 (2020) Pathogens |
ISSN: | 2076-0817 |
Popis: | The Chikungunya virus infection in Brazil has raised several concerns due to the rapid dissemination of the virus and its association with several clinical complications. Nevertheless, there is limited information about the genomic epidemiology of CHIKV circulating in Brazil from surveillance studies. Thus, to better understand its dispersion dynamics in Rio de Janeiro (RJ), one of the most affected states during the 2016–2019 epidemic waves, we generated 23 near-complete genomes of CHIKV isolates from two main cities located in the metropolitan mesoregion, obtained directly from clinical samples. Our phylogenetic reconstructions suggest the 2019-CHIKV-ECSA epidemic in RJ state was characterized by the co-circulation of multiple clade (clade A and B), highlighting that two independent introduction events of CHIKV-ECSA into RJ state have occurred between 2016–2019, both mediated from the northeastern region. Interestingly, we identified that the two-clade displaying eighteen characteristic amino acids changes among structural and non-structural proteins. Our findings reinforce that genomic data can provide information about virus genetic diversity and transmission dynamics, which might assist in the arbovirus epidemics establishing of an effective surveillance framework. |
Databáze: | OpenAIRE |
Externí odkaz: |