Mutational Processes in Hepatocellular Carcinoma: The Story of Aristolochic Acid
Autor: | Eric Letouzé, J.-C. Nault |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Carcinoma Hepatocellular Carcinogenesis Aristolochic acid Endogeny Context (language use) Aristolochia DNA Adducts 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Carcinoma medicine Humans Gene Hepatology biology Liver Neoplasms biology.organism_classification medicine.disease 030104 developmental biology chemistry Hepatocellular carcinoma Mutation Cancer research Aristolochic Acids 030211 gastroenterology & hepatology DNA Drugs Chinese Herbal |
Zdroj: | Seminars in Liver Disease. 39:334-340 |
ISSN: | 1098-8971 0272-8087 |
Popis: | Each hepatocellular carcinoma displays dozens of mutations in driver and passenger genes. The analysis of the types of substitutions and their trinucleotide context defines mutational signatures that recapitulate the endogenous and exogenous mutational processes operative in tumor cells. Aristolochic acid is present in plants from the genus Aristolochia and causes chronic nephropathy. Moreover, aristolochic acid has genotoxic properties responsible for the occurrence of urothelial carcinoma. Metabolites of aristolochic acid form DNA adducts on adenine residues leading to a specific mutational signature with almost exclusively A:T to T:A transversions, preferentially in a CTG trinucleotide context. Interestingly, this mutational fingerprint has been identified in a subset of hepatocellular carcinomas suggesting that aristolochic acid is a new risk factor for hepatocellular carcinoma. More data are warranted to capture the real impact of exposure to aristolochic acid in hepatocellular carcinoma occurrence worldwide. |
Databáze: | OpenAIRE |
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