Myosin binding protein H-like (MYBPHL): a promising biomarker to predict atrial damage

Autor:	Konstantinos Sideris, Lena Eschenbach, Harald Lahm, Marcus-André Deutsch, N. Beck, Karl C. König, Isabel Deisenhofer, Rüdiger Lange, Matthias Mann, Stefanie A. Doppler, Nazan Puluca, Stefanie Voss, Shunsuke Matsushima, Sophia Doll, Markus Krane, M. Dreßen, I. Neb, Stefan Holdenrieder
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	0301 basic medicine Gene isoform medicine.medical_specialty Myofilament Heart Ventricles lcsh:Medicine Predictive markers Cryosurgery Article 03 medical and health sciences 0302 clinical medicine Aortic valve replacement Internal medicine Atrial Fibrillation medicine Humans Protein Isoforms Heart Atria Muscle Skeletal lcsh:Science Peptide sequence Radiofrequency Ablation Multidisciplinary Chemistry lcsh:R Skeletal muscle medicine.disease Up-Regulation ddc Alternative Splicing Cytoskeletal Proteins Intensive Care Units 030104 developmental biology medicine.anatomical_structure Endocrinology Organ Specificity Ventricle Myosin binding Biomarker (medicine) lcsh:Q Biomarkers 030217 neurology & neurosurgery
Zdroj:	Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019) Scientific Reports Lahm, H, Dressen, M, Beck, N, Doppler, S, Deutsch, M-A, Matsushima, S, Neb, I, Koenig, K C, Sideris, K, Voss, S, Eschenbach, L, Puluca, N, Deisenhofer, I, Doll, S, Holdenrieder, S, Mann, M, Lange, R & Krane, M 2019, ' Myosin binding protein H-like (MYBPHL) : a promising biomarker to predict atrial damage ', Scientific Reports, vol. 9, 9986 . https://doi.org/10.1038/s41598-019-46123-w
ISSN:	2045-2322
Popis:	Myosin binding protein H-like (MYBPHL) is a protein associated with myofilament structures in atrial tissue. The protein exists in two isoforms that share an identical amino acid sequence except for a deletion of 23 amino acids in isoform 2. In this study, MYBPHL was found to be expressed preferentially in atrial tissue. The expression of isoform 2 was almost exclusively restricted to the atria and barely detectable in the ventricle, arteria mammaria interna, and skeletal muscle. After atrial damage induced by cryo- or radiofrequency ablation, MYBPHL was rapidly and specifically released into the peripheral circulation in a time-dependent manner. The plasma MYBPHL concentration remained substantially elevated up to 24 hours after the arrival of patients at the intensive care unit. In addition, the recorded MYBPHL values were strongly correlated with those of the established biomarker CK-MB. In contrast, an increase in MYBPHL levels was not evident in patients undergoing aortic valve replacement or transcatheter aortic valve implantation. In these patients, the values remained virtually constant and never exceeded the concentration in the plasma of healthy controls. Our findings suggest that MYBPHL can be used as a precise and reliable biomarker to specifically predict atrial myocardial damage.
Databáze:	OpenAIRE
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