A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity
| Autor: | Yosef Yarom, Rémi Proville, Lea Ankri, Zoé Husson, Stéphane Dieudonné, Clément Léna, Katarzyna Pietrajtis, Marylka Uusisaari |
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| Přispěvatelé: | The Edmond and Lily Safra Center for brain sciences [Jérusalem] (ELSC), The Hebrew University of Jerusalem (HUJ), Institut de biologie de l'ENS Paris (UMR 8197/1024) (IBENS), Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de biologie de l'ENS Paris (IBENS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Département de Biologie - ENS Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2014 |
| Předmět: |
Golgi cell
Cerebellum cerebellum QH301-705.5 Science Models Neurological cerebellar nuclei Biology Inhibitory postsynaptic potential General Biochemistry Genetics and Molecular Biology symbols.namesake Cerebellar Cortex Mice Golgi cells Bernstein Conference Interneurons Cortex (anatomy) Neural Pathways medicine Animals Biology (General) mouse Computational Neuroscience General Immunology and Microbiology General Neuroscience General Medicine Anatomy Golgi apparatus Immunohistochemistry inhibition Cell biology Motor coordination Optogenetics Luminescent Proteins medicine.anatomical_structure nervous system Cerebellar cortex symbols GABAergic Medicine [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Research Article Neuroscience |
| Zdroj: | eLife eLife, eLife Sciences Publication, 2015, 4, ⟨10.7554/eLife.06262⟩ eLife, Vol 4 (2015) |
| ISSN: | 2050-084X |
| Popis: | The cerebellum, a crucial center for motor coordination, is composed of a cortex and several nuclei. The main mode of interaction between these two parts is considered to be formed by the inhibitory control of the nuclei by cortical Purkinje neurons. We now amend this view by showing that inhibitory GABA-glycinergic neurons of the cerebellar nuclei (CN) project profusely into the cerebellar cortex, where they make synaptic contacts on a GABAergic subpopulation of cerebellar Golgi cells. These spontaneously firing Golgi cells are inhibited by optogenetic activation of the inhibitory nucleo-cortical fibers both in vitro and in vivo. Our data suggest that the CN may contribute to the functional recruitment of the cerebellar cortex by decreasing Golgi cell inhibition onto granule cells. DOI: http://dx.doi.org/10.7554/eLife.06262.001 eLife digest The cerebellum is a region in the brain that plays a central role in controlling posture and movement. The cerebellum is composed of a cortex and several nuclei. The nuclei are thought to ‘compute’ the signals that are sent from the cerebellum to other parts of the brain to control posture and movement. They do this under the supervision of the cortex. The main interaction between the cortex and the nuclei involves cortical neurons called Purkinje cells inhibiting the activity of the nuclei. Ankri, Husson et al. have now used various genetic techniques and mutant mice to identify a new population of neurons in the nuclei of the cerebellum and to express fluorescent markers into these cells. This approach reveals that the axons of these neurons ‘climb’ from the nuclei to the cortex to form a new circuit called the inhibitory nucleo-cortical (iNC) pathway. Moreover, activating the iNC axons with light reveals that they selectively target and silence a population of neurons called the Golgi cells, which control the transmission of information in the cerebellar cortex. Ankri, Husson et al. go on to show that the Golgi cells silenced by the iNC pathway differ from other Golgi cells in a number of ways: in particular, these Golgi cells use a chemical called GABA to communicate with neurons. The next challenge is to explore how the iNC pathway fine-tunes how sensory inputs are processed in the cerebellum, and to better understand its role in the execution of complex movements, including in people with conditions that affect motor function, such as ataxias. DOI: http://dx.doi.org/10.7554/eLife.06262.002 |
| Databáze: | OpenAIRE |
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