Evaluation of fetal lung maturity by measurement of the procoagulant activity in amniotic fluid
| Autor: | H. Heyes, K. Musch, W. Leucht |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
medicine.medical_specialty
Amniotic fluid Gestational Age Betamethasone Equivalent Fetal Organ Maturity Pregnancy Internal medicine medicine Humans Lung business.industry Obstetrics and Gynecology Gestational age General Medicine Amniotic Fluid medicine.disease Endocrinology medicine.anatomical_structure Coagulation Fetal lung maturity Prothrombin Time Female business medicine.drug |
| Zdroj: | Archives of Gynecology. 233:7-14 |
| ISSN: | 1432-0711 0170-9925 |
| DOI: | 10.1007/bf02110673 |
| Popis: | The procoagulant activity of amniotic fluid (AF) increases with advancing gestational age. AF samples (N = 276) were measured by a modified recalcification time method. The results were expressed as equivalents of Russell's viper venom (RVV) which acts in a similar way as AF by way of direct activation of coagulation factor X. After week 35 of pregnancy RVV values reached or passed 0.09 micrograms/ml. This value represents a threshold indicating fetal lung maturity. In 124 cases postnatal lung maturity was related to RVV equivalents. The predictive value of a mature result was 99.1%, that of an immature one 52.2%. When comparing RVV values with the lung status, surface tension measurements, and L/S ratio a high correlation was found. L/S ratio and procoagulant activity had a correlation coefficient of r = 0.60. Betamethasone seemed to produce the expected changes in the results of RVV assays and surface tension measurements. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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