Increased Metabolism of Acetaminophen in Chronically Alcoholic Patients
Autor: | Catherine Girre, Eric Hispard, S. Palombo, Sylvain Dally, C. N'Guyen |
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Rok vydání: | 1993 |
Předmět: |
Adult
Male medicine.medical_specialty Metabolic Clearance Rate Metabolite Medicine (miscellaneous) Pharmacology Toxicology Gastroenterology chemistry.chemical_compound Liver Function Tests Pharmacokinetics Risk Factors Internal medicine Humans Medicine Volunteer Acetaminophen Dose-Response Relationship Drug business.industry digestive oral and skin physiology Venous blood Metabolism Middle Aged Bioavailability Alcoholism stomatognathic diseases Psychiatry and Mental health chemistry Toxicity Chemical and Drug Induced Liver Injury business Half-Life medicine.drug |
Zdroj: | Alcoholism: Clinical and Experimental Research. 17:170-173 |
ISSN: | 1530-0277 0145-6008 |
DOI: | 10.1111/j.1530-0277.1993.tb00743.x |
Popis: | The aim of this work was to determine whether the metabolism of acetaminophen increases in chronic alcoholics, and consequently whether the production of its hepatotoxic metabolite is enhanced. For this purpose, the pharmacokinetics of acetaminophen were compared in 12 alcoholic men and 12 healthy controls. After a 12-hr fast, the patients (on the 3rd hospital day) and volunteers were given 1 g of oral acetaminophen at 8.00 AM. Venous blood samples were drawn before drug intake and at regular intervals after to evaluate plasma acetaminophen concentrations. The elimination half-life of acetaminophen was significantly shorter in the alcoholic patients than in the controls (1.70 +/- 0.55 vs. 2.84 +/- 0.30 hr, p < 0.001). Similarly, total plasma acetaminophen clearance was significantly higher in the patients than in the controls (29.19 +/- 13.37 vs. 24.45 +/- 11.10 l/hr, p < 0.05). These results confirm that the metabolism of acetaminophen increases in chronic alcoholism and consequently suggest that its potential liver toxicity might be enhanced. |
Databáze: | OpenAIRE |
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