Protective effect of drugs on histamine-induced asthma
| Autor: | J. J. A. Mellon, D. N. Killian, F. E. Hargreave, Donald W. Cockcroft |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Atropine
Male Pulmonary and Respiratory Medicine Drug medicine.medical_specialty Microgram media_common.quotation_subject Ascorbic Acid Pharmacology Choline chemistry.chemical_compound Internal medicine Cromolyn Sodium medicine Humans Albuterol Theophylline media_common Inhalation business.industry Ipratropium Ascorbic acid Asthma Endocrinology chemistry Choline theophyllinate Salbutamol Female business Histamine Research Article medicine.drug |
| Zdroj: | Thorax. 32:429-437 |
| ISSN: | 0040-6376 |
| DOI: | 10.1136/thx.32.4.429 |
| Popis: | Controlled standardised histamine inhalation tests were carried out in 21 asthmatics to determine the degree of non-specific bronchial hyperreactivity with and without prior treatment with several anti-asthmatic drugs. A significant protective effect was produced by inhaled salbutamol, 200 microgram, ingested salbutamol, 4 mg, inhaled Sch1000, 40 microgram inhaled atropine sulphate, 290 microgram, and ingested choline theophylinate (200 or 400 mg) producing serum theophylline levels over 10 mg/l. Inhaled salbutamol was consistently the most effective and was significantly better than the other drugs. The protective effect between the other four was not significantly different. Drug side-effects occurred only with the ingested drugs. No significant protection was detected after ingested choline theophyllinate producing serum theophylline levels of less than 10 mg/l, inhaled sodium cromoglycate, 20 mg given once or six-hourly for one week, or ingested ascorbic acid, 1 gram. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|