Different effect of laparoscopic Roux-en-Y gastric bypass and open biliopancreatic diversion of Scopinaro on serum PYY and ghrelin levels
| Autor: | Juan Garcia-Arnes, Jose Manuel García-Almeida, Jose L. Gallego-Perales, Federico Soriguer, Jose Rivas-Marín, Sonsoles Morcillo, Isabel Cardona, Eduardo García-Fuentes, Lourdes Garrido-Sánchez |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Gastric Bypass Body Mass Index Weight loss Internal medicine mental disorders Weight Loss medicine Humans Peptide YY Biliopancreatic Diversion Nutrition and Dietetics business.industry digestive oral and skin physiology nutritional and metabolic diseases Middle Aged medicine.disease Roux-en-Y anastomosis Obesity Ghrelin Obesity Morbid Endocrinology Treatment Outcome Surgery Female Analysis of variance medicine.symptom business Body mass index hormones hormone substitutes and hormone antagonists |
| Zdroj: | Obesity surgery. 18(11) |
| ISSN: | 0960-8923 |
| Popis: | The impact of bariatric surgery on levels of peptide YY (PYY) and ghrelin is still under discussion. We undertook a simultaneous evaluation of the serum changes in PYY and ghrelin depending on the specific type of bariatric surgery. Total PYY and ghrelin were analyzed in 29 healthy persons and in morbidly obese persons undergoing open biliopancreatic diversion (BPD) of Scopinaro (n = 38) or laparoscopic Roux-en-Y gastric bypass (RYGB; n = 13). RYGB resulted in a significantly greater loss of weight and body mass index than BPD. Both RYGB and BPD were associated with a significant increase in PYY, significantly greater for BDP (p = 0.001). Ghrelin rose significantly after RYGB (p = 0.022) but not after BPD. After surgery, PYY correlated positively with weight (r = 0.416, p = 0.009). Ghrelin did not correlate significantly with any of the variables studied. Analysis of variance showed that only the type of surgery contributed significantly to explain the variances in the PYY (p = 0.002) and ghrelin (p = 0.018). BPD results in a greater increase in PYY and a lower weight loss than RYGB. However, only RYGB was associated with a significant increase in ghrelin. The differing weight loss according to the type of bariatric surgery does not seem to be explained by changes arising in PYY and ghrelin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink