Neuroprotective effect of human osteogenic protein-1 in a rat model of cerebral hypoxia/ischemia
| Autor: | G. Perides, David C. Rueger, Michael E. Charness, Frances E. Jensen, Paul Edgecomb |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Pathology
medicine.medical_specialty Neutrophils Bone Morphogenetic Protein 7 medicine.medical_treatment Rat model Intraperitoneal injection Ischemia Pharmacology Neuroprotection Brain Ischemia Transforming Growth Factor beta medicine Animals Carotid ligation Hypoxia Cerebral Hypoxia-Ischemia business.industry General Neuroscience Temperature Proteins Cerebral hypoxia Hypoxia (medical) medicine.disease Rats Disease Models Animal Bone Morphogenetic Proteins medicine.symptom business |
| Zdroj: | Neuroscience Letters. 187:21-24 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(95)11327-s |
| Popis: | Possible neuroprotective actions of osteogenic protein-1 (OP-1) were evaluated in a rat model of cerebral hypoxia/ischemia. Intraperitoneal injection of 50 micrograms of OP-1 prior to bilateral carotid ligation and transient hypoxia in 12-day-old rats reduced cerebral infarct area from 44.8 +/- 3.3% in vehicle-injected controls to 29 +/- 4.9%. Treatment of 14-day-old rats with 20 micrograms of OP-1 1 h after hypoxia reduced mortality from 45% to 13%. OP-1 may represent a novel class of neuroprotective agents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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