EPITHELIOTROPIC INTESTINAL T-CELL LYMPHOMA IN A HARBOR SEAL (PHOCA VITULINA)
| Autor: | Christiane Herden, Manfred Henrich, Henrike Alma Gregersen, Sara Malberg |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty 040301 veterinary sciences CD3 Population Phoca Lymphoma T-Cell 0403 veterinary science 03 medical and health sciences Intestinal Neoplasms medicine Animals Neoplasm education Lymph node education.field_of_study General Veterinary biology 04 agricultural and veterinary sciences General Medicine medicine.disease biology.organism_classification Lymphoma 030104 developmental biology medicine.anatomical_structure biology.protein Harbor seal Immunohistochemistry Animal Science and Zoology |
| Zdroj: | Journal of Zoo and Wildlife Medicine. 48:568-572 |
| ISSN: | 1937-2825 1042-7260 |
| DOI: | 10.1638/20160221r.1 |
| Popis: | A 14-yr- old, male harbor seal (Phoca vitulina) presented with depression, anorexia, and weight loss. Clinical examination revealed no specific abnormalities. Diagnostic imaging displayed an enlarged mass in the dorso-cranial abdomen. The animal was euthanized due to progressive worsening of symptoms. Grossly, severe emaciation and a massive enlargement of one mesenteric lymph node were found. Microscopically, a neoplastic round cell population with morphologic characteristics of mature lymphocytes infiltrated the mesenteric lymph node as well as the jejunal mucosa and exhibited a marked invasion of the mucosal epithelial layer. Immunohistochemically, the majority of cells expressed CD3, but not CD79α, indicating a T-cell origin of the tumor cells. Microscopic as well as immunohistochemical findings enabled the diagnosis of an epitheliotropic intestinal T-cell lymphoma, a neoplasm that has yet not been described in a harbor seal. |
| Databáze: | OpenAIRE |
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